Hello All,
While researching I found out some interesting information about Hypokalemic Periodic Paralysis. A study from 2001 relates two different types: CACNL1A3=Hypokalemic Periodic Paralysis-1 and SCN4A=Hypokalemic Periodic Paralysis-2, each with several mutations.
When someone is diagnosed with Hypokalemic
Periodic Paralysis, clinically, (based on their symptoms), one must be very
careful. One form either does not respond to diamox (acetazolamide), causes
more paralysis or causes serious symptoms. So,
diamox should not automatically be given to people clinically diagnosed with Hypokalemic
Periodic Paralysis or if it is, it should be used with extreme caution.
From the
article:
“In conclusion
the present study demonstrates that genetic
characterization of hypoPP patients is important to
decipher
the clinical and histopathological features of the
disease, and
to predict the response to therapy. We suggest that
mutations
in the SCN4A gene should be systematically sought
in hypoPP
patients suffering from paralytic attacks followed
by myalgias
or worsened by acetazolamide, and when muscle
biopsies reveal the presence of tubular aggregates.”
http://brain.oxfordjournals.org/content/124/6/1091.full.pdf
Until later….
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