Comprehensive List of Drugs That Cause Potassium Shifts Affecting People with Periodic Paralysis

Comprehensive List of Drugs That Cause Potassium Shifts Affecting People with Periodic Paralysis

Periodic Paralysis (PP) is a group of genetic disorders characterized by episodes of muscle weakness or paralysis, often triggered by shifts in potassium levels. It is crucial for individuals with PP to avoid drugs that can cause significant potassium shifts. Here is a comprehensive list of such drugs, categorized by their primary use, along with references for further information.

Diuretics

• Thiazide Diuretics: Can cause hypokalemia (low potassium levels).
• Hydrochlorothiazide
• Chlorthalidone
• Loop Diuretics: Can cause significant potassium depletion.
• Furosemide (Lasix)
• Bumetanide
• Potassium-Sparing Diuretics: Can cause hyperkalemia (high potassium levels).
• Spironolactone
• Eplerenone

Beta-Blockers

• Non-selective Beta-Blockers: Can affect potassium levels by altering renal function.
• Propranolol
• Nadolol
• Carvedilol

ACE Inhibitors and ARBs

• ACE Inhibitors: Can cause hyperkalemia.
• Lisinopril
• Enalapril
• Ramipril
• ARBs (Angiotensin II Receptor Blockers): Can cause hyperkalemia.
• Losartan
• Valsartan
• Olmesartan

Antibiotics

• Penicillins: High doses can cause shifts in potassium levels.
• Penicillin G
• Amoxicillin
• Trimethoprim-Sulfamethoxazole (Bactrim): Can cause hyperkalemia.

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

• Common NSAIDs: Can affect kidney function, leading to potassium imbalances.
• Ibuprofen
• Naproxen
• Indomethacin

Antifungals

• Azole Antifungals: Can cause potassium shifts and should be used with caution.
• Ketoconazole
• Itraconazole

Cardiac Glycosides

• Digoxin: Can cause both hypo- and hyperkalemia depending on the context and dosage.

Others

• Heparin: Can cause hyperkalemia by inhibiting aldosterone synthesis.
• Trimethoprim: Found in combination with sulfamethoxazole, can cause hyperkalemia.
• Tacrolimus: An immunosuppressant that can cause hyperkalemia.

References

1. Diuretics and Potassium Balance:
• MedlinePlus. Thiazide diuretics
• MedlinePlus. Loop diuretics
• MedlinePlus. Potassium-sparing diuretics
2. Beta-Blockers and Potassium:
• Drugs.com. Beta-blockers
3. ACE Inhibitors and ARBs:
• Mayo Clinic. ACE inhibitors
• Mayo Clinic. ARBs
4. Antibiotics:
• U.S. Pharmacist. Antibiotics and Potassium
5. NSAIDs:
• Cleveland Clinic. NSAIDs and Electrolyte Imbalance
6. Antifungals:
• MedlinePlus. Azole antifungals
7. Cardiac Glycosides:
• MedlinePlus. Digoxin
8. Others:
• Drugs.com. Heparin
• MedlinePlus. Trimethoprim
• Mayo Clinic. Tacrolimus

Individuals with Periodic Paralysis should always consult with their healthcare providers before starting or stopping any medication to manage their condition effectively. Regular monitoring and a personalized treatment plan are crucial for avoiding adverse effects related to potassium shifts.

Image: Pills with “NO” on them to remind people with Periodic Paralysis of the dangers of drugs.