Most of us have been diagnosed with medical conditions, which co-exist with our Periodic Paralysis. There is a good reason for this. Research shows that metabolic disorders (PP is a mineral metabolic disorder) cause damage to the mitochondria creating mitochondrial issues/dysfunction (in my case lactic acidosis, exercise intolerance) this mito damage then creates autoimmune disorders/dysfunction (in my case...fibromyalgia, osteoarthiritis, osteporosis, peripheral neuropathy, allergies, and much more etc)
The diseases co-existing with your PP may be an indication of the advancement of the damage to your mitochondria and autoimmune system...I have used this information to create a method for diagnosing PP which includes the degree of progression or ‘level’, and the ‘stage’ to which it has developed.
From the "Periodic Paralysis Guide and Workbook"......
The Instructions (for the new chart):
The Number of Years Without a Diagnosis?
Age at diagnosis minus the age at the sign of the first symptom
Episodes of Paralysis or Muscle weakness?
Yes or No
Andersen-Tawil Syndrome Characteristics?
Yes or No
Form of Periodic Paralysis?
Based on Symptoms and Characteristics
Co-existing Conditions?
List and count then check the types: Autoimmune, Mitochondrial, Auto inflammatory or ?
Degree or Level of Progression?
Permanent muscle weakness? Exercise Intolerance? Permanent heart damage? Breathing muscle weakness? Other permanent Issues?
Check and count
Stage of Periodic Paralysis?
Stage One=periods of muscle weakness, or partial or full-body paralysis.
Stage Two=periods of muscle weakness, or partial or full-body paralysis and PP+ 1-10 (or more)
Stage Three= periods of muscle weakness, or partial or full-body paralysis and PP+ 1-10 (or more) and Autoimmune Dysfunction
Stage Four=periods of muscle weakness, or partial or full-body paralysis and PP+ 1-10 (or more) and Mitochondrial Dysfunction
Stage Five=periods of muscle weakness, or partial or full-body paralysis and PP+ 1-10 (or more) and Mitochondrial Dysfunction and Autoimmune Dysfunction
This formula is very clear to understand. It is a sensible, practical and a more reliable way to diagnose Periodic Paralysis.
Here is a list of Autoimmune Diseases/Disorders/Dysfunction and Mitochondrial Diseases/Disorders/Dysfunction
From the "Periodic Paralysis Guide and Workbook":
Have you been diagnosed with allergies, autoimmune and/or inflammatory diseases?
all related to autoimmune dysfunction
ALLERGIES, AUTOIMMUNE & INFLAMMATORY DISEASES
(All Autoimmune)
AUTOIMMUNE DISEASES
Addison's disease
Alopecia areata
Ankylosing spondylitis
Autoimmune angioedema
Autoimmune aplastic anemia
Autoimmune dysautonomia
Autoimmune hepatitis
Autoimmune hyperlipidemia
Autoimmune immunodeficiency
Autoimmune inner ear disease
Autoimmune myocarditis
Autoimmune oophoritis
Autoimmune pancreatitis
Autoimmune retinopathy
Autoimmune thrombocytopenic purpura
Autoimmune thyroid disease
Autoimmune urticaria
Axonal & neuronal neuropathies
Behcet’s disease
Cardiomyopathy
Celiac disease
Chronic fatigue syndrome
Chronic inflammatory demyelinating
Polyneuropathy
Chronic recurrent multifocal ostomyelitis
Crohn’s disease
Congenital heart block
CREST disease
Demyelinating neuropathies
Dermatomyositis
Discoid lupus
Dressler’s syndrome
Endometriosis
Fibromyalgia
Glomerulonephritis
Goodpasture’s syndrome
Graves' disease
Guillain-Barre syndrome
Hashimoto's encephalitis
Hashimoto’s thyroiditis
Hemolytic anemia
Immunoregulatory lipoproteins
Inclusion body myositis
Interstitial cystitis
Juvenile arthritis
Juvenile diabetes (Type 1 diabetes)
Juvenile myositis
Kawasaki syndrome
Lambert-Eaton syndrome
Lichen planus
Lichen sclerosus
Lupus
Lyme disease, chronic
Meniere’s disease
Mixed connective tissue disease
Multiple sclerosis
Myasthenia gravis
Myositis
Narcolepsy
Neutropenia
Optic neuritis
Peripheral neuropathy
Pernicious anemia
Polymyalgia rheumatica
Polymyositis
Progesterone dermatitis
Primary biliary cirrhosis
Psoriasis
Psoriatic arthritis
Idiopathic pulmonary fibrosis
Raynauds phenomenon
Reactive Arthritis
Reflex sympathetic dystrophy
Reiter’s syndrome
Relapsing polychondritis
Restless legs syndrome
Rheumatic fever
Rheumatoid arthritis
Sarcoidosis
Scleroderma
Sjogren's syndrome
Stiff person syndrome
Subacute bacterial endocarditis
Type I diabetes
Ulcerative colitis
Undifferentiated connective tissue dis.
Vasculitis
INFLAMMATORY DISEASES
ALS
Addison's disease
Aging (senescence)
Allergies and sensitivities
Anemia
Ankylosing spondylitis
Anorexia and bulimia
Anxiety
Asthma
Autism spectrum disorder
Baldness (alopecia)
Bipolar Disorder (manic-depression)
Cancer
Cardiovascular diseases
Cat scratch fever
Celiac disease
Chronic Lyme disease
Chronic fatigue syndrome
Co-infections
Cognitive dysfunction (brain fog)
Depression
Diabetes, Type II
Epilepsy (seizures)
Eye diseases
Fibromyalgia
Graves' disease
Hashimoto's disease
Headaches and migraines
Hypercalcemia
Hypertension (high blood pressure)
Inflammatory bowel disease (Crohn's disease and ulcerative colitis)
Irritable bowel
Kidney disease
Kidney stones
Learning disabilities (ADHD, ADD, dyslexia)
Mental and neurological conditions
Multiple chemical sensitivity
Multiple sclerosis
Obesity
Obsessive-compulsive disorder
Osteoarthritis
Osteoporosis and osteopenia
Parkinson's disease
Periodontal disease and gingivitis
Peripheral neuropathy
Pernicious anemia
Psoriasis
Raynaud's syndrome
Reiter's syndrome
Restless leg syndrome
Rheumatoid arthritis
Sarcoidosis
Schizophrenia
Scleroderma
Secondary hyperparathyroidism
Systemic lupus erythematosus
Cystic fibrosis
Diabetes, Type I
HIV and AIDS
Rickets
MITOCHONDRIAL DISEASES
Alzheimer's Disease
Parkinson’s' Disease
Ataxia, myoclonus and deafness
chronic intestinal pseudo obstruction with myopathy and ophthalmoplegia
Chronic Progressive External ophthalmoplegia
Cyclic Vomiting Syndrome
Maternally inherited deafness or Aminoglycoside-induced deafness
Dementia and chorea
Diabetes mellitus and deafness
Exercise intolerance
Epilepsy, strokes, optic atrophy and cognitive decline
Familial bilateral striatal necrosis
Fatal Infantile cardiomyopathy plus, a MELAS-associated cardiomyopathy
Gastrointestinal reflux
Kearns Sayre Syndrome
Leber's Hereditary Optic Neuropathy and Dystonia
Leber Hereditary Optic Neuropathy
Lethal Infantile Mitochondrial Myopathy
Myopathy and Diabetes Mellitus
Mitochondrial Encephalomyopathy, Lactic acidosis and stroke-like episodes
Myoclonic epilepsy and psychomotor regression
Myoclonic epilepsy and ragged red muscle fibers
Maternally inherited diabetes and deafness
Maternally Inherited hypertrophic cardiomyopathy
Maternally inherited cardiomyopathy
Maternally Inherited Leigh Syndrome
Mitochondrial encephalocardiomyopathy
Mitochondrial encephalomyopathy
Mitochondrial myopathy
Maternal myopathy and cardiomyopathy
Multisystem Mitochondrial Disorder
(myopathy, encephalopathy, blindness,
hearing loss, peripheral neuropathy)
Neurogenic muscle weakness, Ataxia, and Retinitis Pigmentosa; alternate
phenotype at this locus is reported as
Leigh Disease
Non-Insulin Dependent Diabetes Mellitus
Progressive Encephalopathy
Progressive Myoclonus Epilepsy
Rett Syndrome
Sudden Infant Death Syndrome
Sensorineural hearing loss
MITOCHONDRIAL DYSFUNCTION
Cancers (some)
Exercise intolerance
Strokes
Seizures
Gastrointestinal problems (reflux, vomiting, constipation, diarrhea)
Swallowing difficulties
Failure to thrive
Blindness
Deafness
Heart and kidney problems
Muscle failure
Heat/cold intolerance
Diabetes
Lactic acidosis
Immune system problems
Liver disease
I hope this is helpful to some of you....
More information is in the "The Periodic Paralysis Guide And Workbook"
PPNI Periodic Paralysis Diagnosis Chart
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