I was asked the question, “Can Periodic Paralysis (PP) be caused by other or secondary causes such as vitamin deficiency, vaccinations or toxic exposure or is there always a genetic or inherited cause?”
My answer is:
For those of us with the varying forms of Periodic Paralysis (a mineral metabolic disorder, also known as an ion channelopathy,) the cause is almost entirely/exclusively genetically related. Secondary causes, in my mind, do not exist but others believe they do. I believe that those people actually have/had the genetic mutation but nothing introduced in their life set it into motion until the vaccination, illness, toxic exposure or more that they believe caused it. Those things are/were triggers that set symptoms/paralysis into motion, but the predisposition, a genetic mutation, was already there (inherited, we are born with it). As far as I know, there is no proof that there are secondary causes for PP. There are definite genetic mutations related to the known forms of PP. There are several other medical conditions called 'differential diagnoses' that have similar symptoms like Sjogren's, Bartter Syndrome, Conn Syndrome, Multiple Sclerosis, Hyperaldosteronism and these must be ruled out before a diagnosis is confirmed.
The following are the typical genetic mutations for most of the known forms of PP:
Hypokalemic Periodic Paralysis is caused by abnormalities in the SCN4A, KCNJ18 and CACNA1S genes.
Thyrotoxic Periodic Paralysis is caused by abnormalities in the KCNE3, KCNJ18, SCN4A and CACNA1S genes. (most cases are not linked to these genetic mutations...most are from malfunctioning thyroids)
K= potassium channelopathy
C= calcium channelopathy