Happy 11th Anniversary Periodic Paralysis Network!!!
Providing HOPE to individuals with Periodic Paralysis for eleven years!!!
Monday, February 7, 2022
Happy 11th Anniversary Periodic Paralysis Network!!!
Osteoporosis and Periodic Paralysis
Osteoporosis and Periodic Paralysis
Periodic Paralysis is a 4th Class Mineral Metabolic Disorder.
"In general, the genetic metabolic disorders are caused by genetic defects
that result in missing or improperly constructed enzymes necessary for some
step in the metabolic process of the cell.
The three largest classes of metabolic disorders are:
Glycogen storage diseases -- disorders affecting carbohydrate metabolism
Fatty oxidation disorders -- disorders affecting the metabolism of fat
components
Mitochondrial disorders -- disorders affecting the mitochondria which are the
central "powerhouses" of the cells.
**A fourth class, the channelopathies (some of which cause periodic
paralysis and/or malignant hyperthermia) could be considered to be metabolic disorders
as well, though they are not always classified as such. These disorders affect
the ion channels in the cell and organelle membranes, resulting in improper or
inefficient transfer of ions through the membranes." **
https://sites.google.com/site/metaboliccare/metabolicdisorder
http://www.encognitive.com/node/1181
https://ufhealth.org/mineral-metabolism-disorders
How does this relate to osteoporosis?
Periodic Paralysis is a mineral metabolic disorder, due to that, chronic
metabolic acidosis can develop in many of us with Periodic Paralysis. As such,
it can affect our bones.
"Metabolic acidosis may effect changes in bone by directly inducing
dissolution of bone,..."
"...As a consequence, in some patients with normal renal function,
osteoporosis and osteomalacia have been reported that are linked in part to
metabolic acidosis. ..."
https://pubmed.ncbi.nlm.nih.gov/7614335/
”Metabolic acidosis has been shown to lead to calcium loss
from bone (7, 8), to inhibit osteoblast function and stimulate osteoclast activity (9, 10), and to impair bone mineralization (11).”
https://academic.oup.com/jcem/article/98/1/207/2823184
“Metabolic acidosis increases urine calcium excretion without an increase in intestinal calcium absorption, resulting in a net loss of bone mineral.”
”When your electrolyte levels are out of balance (Low)…, you experience an acid/base (pH) imbalance. Specifically, your pH levels decrease, creating metabolic acidosis. Symptoms include confusion, fatigue, headache and increased heart rate. If your electrolyte levels are out of control (High)…, your pH levels increase, causing metabolic alkalosis...”
Here is one study that touches on the
relationship between potassium levels and osteoporosis (from Korea):
”The western diet including high meats and cereal grains
produces a low-grade metabolic acidosis [11].
The continual release of alkaline salts from bone for acid-base balance would
cause bone loss and osteoporosis [13].
Fruit and vegetable intake could balance this excess acidity by providing
alkaline salts of potassium [14].
Thus, the alkaline potassium salt is thought to prevent bone resorption for pH
homeostasis [15].
In addition, increasing potassium intake increases urinary retention, reducing
loss of calcium and thus creating a more positive calcium balance and
inhibiting bone resorption [16,17].
The potassium bicarbonate, but not sodium bicarbonate, reduced urinary calcium
excretion in healthy men [18],
and the potassium citrate reduced urinary calcium excretion in men with uric
acid nephrolithiasis [19].
It suggests that the positive effect of potassium could be through either
suppressing calcium resorption or bone mineral dissolution or both [20].”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997142/